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Updated: Aug 9, 2026

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
Published on: January 7, 2019
Immune mediated cartilage destruction
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8886.
Abstract:
We review the pathogenic role of immune complexes attached to articular cartilage in rheumatoid arthritis. The available evidence suggests that these immune complexes may contribute to irreversible cartilage damage and loss of joint function. In addition, tenacious binding of these complexes to collagenous tissues, possibly by the establishment of covalent bonds, may constitute an important chronicity factor in this disease. The biochemical mechanisms that may be responsible for covalent cross-linking of macromolecules in inflammatory foci are discussed.
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