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Astatine.

Geerd-J Meyer1

  • 1Klinik für Nuklearmedizin/Radiopharmazeutische Chemie, Medizinische Hochschule Hannover, Hannover, Germany.

Journal of Labelled Compounds & Radiopharmaceuticals
|October 29, 2017
PubMed
Summary

Astatine (element 85) discovery and characterization are reviewed. Its isotopes, particularly 211At, are crucial for targeted alpha therapy research, despite challenges in astatine

Area of Science:

  • Radiochemistry
  • Nuclear Chemistry
  • Medical Physics

Background:

  • Astatine (element 85) is a rare halogen with unique radioactive properties.
  • Its longest-lived isotopes, 210At and 211At, exhibit alpha decay suitable for research.
  • Characterization is challenging due to the absence of stable isotopes.

Purpose of the Study:

  • To review the historical discovery and characterization of astatine.
  • To explore the use of astatine isotopes in targeted alpha radiation therapy.
  • To summarize labeling strategies for astatinated radiopharmaceuticals.

Main Methods:

  • Review of historical experiments for astatine discovery and characterization.
  • Analysis of alpha decay characteristics of 210At and 211At.

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  • Examination of various radiolabeling strategies (nucleophilic, electrophilic, complexation).

    • Main Results:

    • Astatine's physical and chemical properties were compared to iodine.
    • The alpha decay of 211At shows promise for targeted alpha therapy.
    • Diverse labeling strategies have been developed to overcome chemical challenges.

    Conclusions:

    • Astatine's unique properties and radioactivity make it valuable for targeted alpha therapy.
    • Developing effective radiopharmaceuticals requires overcoming astatine's distinct chemical behavior.
    • Ongoing research focuses on innovative labeling techniques for astatine-based therapies.