Enzymatic syntheses of 3'-halotyramines, selectively 2H- and 3H-labeled in the side chain
Małgorzata Pająk1, Marianna Kańska2
1Warsaw University, Department of Chemistry, Pasteur 1 Str., 02-093 Warsaw, Poland.
Abstract:
3'-Halotyramines, stereo-selectively labeled with deuterium and tritium, in the (1R) or (1S) position were synthesized using enzymatic methods. The isotopomers labeled in the (1R) position were synthesized by enzymatic decarboxylation of an appropriate 3'-halo-L-tyrosine in deuterated or tritiated incubation medium. The isotopomers labeled in the (1S) position were synthesized by decarboxylation of an appropriate 3'-halo-L-tyrosine, labeled with deuterium or tritium in the α-position of the side chain.
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