Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fucose dependent rotavirus and norovirus require fucosidase activity for optimal replication.

Npj viruses·2025
Same author

Proliferative Cell Targeting and Epithelial Cell Turnover Fuels Hepatitis E Virus Replication in Human Intestinal Enteroids.

Gastro hep advances·2025
Same author

A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo.

Science advances·2025
Same author

Meeting report: 38th international conference on antiviral research in Las Vegas, United States of America, March 17-21, 2025.

Antiviral research·2025
Same author

The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent.

Viruses·2025
Same author

Human norovirus disturbs intestinal motility and transit time through its capsid proteins.

PLoS pathogens·2024

Related Experiment Video

Updated: Feb 19, 2026

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus
13:48

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

Published on: June 24, 2012

17.3K

Interferon lambda (IFN-λ) efficiently blocks norovirus transmission in a mouse model.

Joana Rocha-Pereira1, Sophie Jacobs2, Sam Noppen1

  • 1KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.

Antiviral Research
|October 30, 2017
PubMed
Summary

Interferon lambda (IFN-λ) administration prevents norovirus transmission and disease in mice. This discovery offers a potential new strategy for controlling norovirus outbreaks and protecting vulnerable populations.

More Related Videos

Rescue of Recombinant Newcastle Disease Virus from cDNA
10:55

Rescue of Recombinant Newcastle Disease Virus from cDNA

Published on: October 11, 2013

20.4K
Influenza A Virus Studies in a Mouse Model of Infection
10:44

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

30.0K

Related Experiment Videos

Last Updated: Feb 19, 2026

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus
13:48

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

Published on: June 24, 2012

17.3K
Rescue of Recombinant Newcastle Disease Virus from cDNA
10:55

Rescue of Recombinant Newcastle Disease Virus from cDNA

Published on: October 11, 2013

20.4K
Influenza A Virus Studies in a Mouse Model of Infection
10:44

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

30.0K

Area of Science:

  • Immunology
  • Virology
  • Gastroenterology

Background:

  • Human noroviruses cause widespread gastroenteritis outbreaks due to efficient person-to-person transmission.
  • Current norovirus outbreak control relies on disinfection and isolation, highlighting the need for novel strategies.
  • Developing models to study norovirus transmission is crucial for advancing control measures.

Purpose of the Study:

  • To investigate the role of interferon lambda (IFN-λ) in controlling norovirus infection using a mouse model.
  • To assess the protective potential of IFN-λ against murine norovirus (MNV) transmission and disease.

Main Methods:

  • A mouse-to-mouse transmission model was established using MNV-infected mice and sentinel AG129 mice (deficient in IFN-α/β and IFN-γ receptors).
  • Sentinel mice received an IFN-λ expression plasmid, leading to circulating IFN-λ and gut IFN-stimulated gene (ISG) expression.
  • Protection against MNV-induced disease, replication, inflammation, and immune response was evaluated post-exposure.

Main Results:

  • Sentinel mice exposed to MNV-infected littermates developed MNV infection and diarrhea.
  • IFN-λ administration prevented MNV-induced disease, suppressed viral replication in the small intestine, and reduced inflammation.
  • IFN-λ treatment also inhibited the development of a specific IgG-based immune response to MNV.

Conclusions:

  • Interferon lambda (IFN-λ) alone can confer protection against norovirus transmission.
  • IFN-λ administration effectively controls MNV infection and associated pathology in a susceptible mouse model.
  • Developing simple IFN-λ delivery methods could offer a novel strategy for norovirus outbreak control and protection of at-risk groups.