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Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
Published on: November 30, 2022
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[A cryobank as an attribute of omics technologies]
A A Sazanov1, Kh Kh Erganokov2, E Pfeifer3
1Saint-Petersburg State Technological Institute, Saint-Petersburg, Russia.
Biomeditsinskaia Khimiia
|October 30, 2017
Summary
Biobanks standardize sample collection and storage using SOPs and ISBER guidelines. Next Generation Biobanking advances omics research with detailed patient data and advanced sequencing for personalized medicine.
Area of Science:
- Biobanking and Repository Science
- Biotechnology
- Genomics and Personalized Medicine
Background:
- Biobanks are crucial for research, requiring standardized operating procedures (SOPs) and adherence to International Society for Biological and Environmental Repositories (ISBER) guidelines.
- Cryobanks, operating at -196°C to -150°C, ensure optimal cell viability and preservation of biological molecules for various applications.
- Next Generation Biobanking integrates omics technologies, including Next Generation Sequencing (NGS), for comprehensive biomarker annotation and longitudinal patient data collection.
Purpose of the Study:
- To highlight the critical role of standardization in biobanking operations.
- To emphasize the significance of cryobanking for advanced medical and biotechnological applications.
- To introduce the concept and requirements of Next Generation Biobanking for omics research and personalized medicine.
Main Methods:
- Adherence to established standard operating procedures (SOPs) for sample acquisition, processing, and storage.
- Utilization of specialized software for sample labeling, annotation, and automated monitoring of storage conditions.
- Application of Next Generation Sequencing (NGS) techniques for detailed biomarker annotation and integration of physiological, biochemical, and clinical data.
Main Results:
- Standardized biobanking ensures sample integrity and facilitates reliable research outcomes.
- Cryobanking preserves biological samples effectively, supporting advancements in personalized medicine and biotechnology.
- Next Generation Biobanking enables deep molecular profiling and longitudinal studies, crucial for understanding complex diseases and developing targeted therapies.
Conclusions:
- Standardization and cryopreservation are fundamental to effective biobanking.
- Next Generation Biobanking represents a paradigm shift, necessitating new ethical frameworks for the post-genomic era.
- The integration of omics data and detailed clinical information in biobanks is essential for future medical breakthroughs.
