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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
Published on: February 16, 2015
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Ganoderic acid, lanostanoid triterpene: a key player in apoptosis.
Balraj Singh Gill1, Navgeet2, Richa Mehra3
1Centre for Biosciences, Central University of Punjab, Bathinda, India. gillsinghbalraj@gmail.com.
Investigational New Drugs
|October 30, 2017
Summary
Ganoderma lucidum's ganoderic acid induces apoptosis in cancer cells by targeting key signaling pathways. This mushroom compound modulates receptor tyrosine kinases (RTKs) and downstream signaling, offering potential anti-cancer effects.
Area of Science:
- Oncology
- Pharmacology
- Biochemistry
Background:
- Cancer involves uncontrolled cell proliferation and immune system weakening.
- Apoptosis, a programmed cell death, is crucial for maintaining cellular balance.
- Ganoderma lucidum, a medicinal mushroom, exhibits anti-cancer properties.
Purpose of the Study:
- To review the role of Ganoderma lucidum's ganoderic acid in inducing apoptosis in cancer.
- To highlight the modulation of cancer-signaling pathways by ganoderic acid.
Main Methods:
- Literature review focusing on ganoderic acid's interaction with cancer signaling.
- Analysis of ganoderic acid's effects on receptor tyrosine kinases (RTKs) and downstream pathways.
- Examination of ganoderic acid's impact on NF-κB, RAS-MAPK, PI3K/Akt/mTOR, and cell cycle regulation.
Main Results:
- Ganoderic acid, a major terpenoid in G. lucidum, interacts with RTKs like EGFR, VEGFR, and IGFR.
- It modulates critical cancer signaling pathways including NF-κB, RAS-MAPK, and PI3K/Akt/mTOR.
- These interactions lead to the induction of apoptosis and cell cycle arrest in cancer cells.
Conclusions:
- Ganoderic acid is a key bioactive compound in Ganoderma lucidum with significant apoptosis-inducing effects in cancer.
- Targeting RTKs and associated signaling pathways with ganoderic acid presents a promising therapeutic strategy for cancer treatment.
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