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Peptide Bonds

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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Signal sequences are short amino acid sequences that guide newly synthesized proteins to their proper location within the cell. Classical signal sequences are fifteen to sixty amino acids long and present at the N-terminus of a polypeptide chain. Each signal sequence has a conserved segment of basic residues towards their N terminus, a hydrophobic core, and a C-terminus rich in polar residues. The C-terminus also contains a signal cleavage site and features a -3 -1 sequence motif. The -3-1...

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Updated: Feb 19, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Solid-Binding Peptides in Biomedicine.

Andrew Care¹, Peter L Bergquist^2,3,4, Anwar Sunna^5,6

¹Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, NSW, Australia.

Advances in Experimental Medicine and Biology

|October 30, 2017

Summary

Solid-binding peptides (SBPs) are versatile tools in nanobiotechnology, enabling the functionalization of nanomaterials. These peptides offer precise control for biomedical applications by selectively binding to inorganic surfaces.

Keywords:

Bioconjugation Biomaterials Biomedicine Functionalization Solid-binding peptides

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Last Updated: Feb 19, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

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Published on: February 27, 2019

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

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Published on: March 6, 2017

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

Published on: May 15, 2012

Area of Science:

Nanobiotechnology
Materials Science
Biomedical Engineering

Background:

Solid-binding peptides (SBPs) are increasingly utilized as molecular building blocks in nanobiotechnology.
SBPs exhibit high affinity and selectivity for diverse inorganic surfaces, including metals, oxides, semiconductors, and minerals.

Purpose of the Study:

To describe Solid-binding peptides (SBPs) and their role in nanobiotechnology.
To highlight the potential applications of SBPs in biomedicine, focusing on nanomaterial functionalization.

Main Methods:

Review of literature on Solid-binding peptides (SBPs) and their applications.
Analysis of SBP capabilities in nanomaterial synthesis, assembly, and functionalization.

Main Results:

SBPs facilitate bioconjugation, enhancing biocompatibility and controlling the orientation of nanoscale entities on solid supports.
SBPs are employed in controlled nanomaterial synthesis, hybrid biomaterial formation, and protein immobilization.

Conclusions:

Solid-binding peptides (SBPs) offer a versatile platform for advanced nanobiotechnological applications.
SBPs hold significant potential for developing novel diagnostic and therapeutic nanomaterials for biomedicine.