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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

868
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

952
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

41
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Related Experiment Video

Updated: Feb 19, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

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Peptides and Drug Delivery.

Kavisha R Ulapane1, Brian M Kopec2, Mario E G Moral2

  • 1Department of Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, KS, 66047, USA.

Advances in Experimental Medicine and Biology
|October 30, 2017
PubMed
Summary

Peptides offer targeted drug delivery to specific cells, like cancer cells, minimizing side effects. They also enhance drug transport across intestinal and blood-brain barriers by modulating cell junctions.

Keywords:
Blood-brain barrierBrain deliveryIntestinal mucosa barrierModulator of intercellular junctionsPeptide-drug conjugatePeptide-particle conjugateTargeted drug delivery

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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
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Last Updated: Feb 19, 2026

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
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Area of Science:

  • Biotechnology
  • Pharmacology
  • Drug Delivery Systems

Background:

  • Peptides are increasingly used as therapeutic and diagnostic agents.
  • Their receptor selectivity enables targeted drug delivery to specific cell types, reducing side effects.
  • Peptides are being explored to overcome biological barriers like the intestinal mucosa barrier (IMB) and blood-brain barrier (BBB).

Purpose of the Study:

  • To review the application of peptides in targeted drug delivery.
  • To explore the use of peptides in enhancing drug permeability across the IMB and BBB.
  • To discuss the potential of peptide-mediated drug delivery for future therapies.

Main Methods:

  • Drug conjugation to carrier peptides for receptor-mediated targeting.
  • Utilizing peptides derived from intercellular junction proteins to modulate barrier permeability.
  • Investigating paracellular pathway enhancement for drug transport.

Main Results:

  • Carrier peptides successfully target drugs to specific cells, e.g., cancer cells, via receptor recognition.
  • Peptides derived from junction proteins enhance drug delivery across the IMB and BBB.
  • These peptides facilitate the transport of various molecules, including large proteins like albumin, across barriers.

Conclusions:

  • Peptide-based drug delivery systems offer high specificity and reduced systemic toxicity.
  • Modulator peptides show significant potential for improving oral and brain drug delivery.
  • This approach holds promise for enhancing the efficacy of both therapeutic and diagnostic agents.