Related Experiment Video

Updated: Feb 19, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.9K

Effect of cesarean section on relapse of childhood idiopathic nephrotic syndrome

Takahisa Kimata1, Jiro Kino1, Sohsaku Yamanouchi1

  • 1Department of Pediatrics, Kansai Medical University, Osaka, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|October 30, 2017
PubMed

Insights

Cesarean delivery (CS) is linked to a higher risk of relapse in children with idiopathic nephrotic syndrome (INS). This finding suggests a potential connection between birth method and disease recurrence in pediatric nephrology.

Area of Science:

  • Pediatric Nephrology
  • Obstetrics and Gynecology

Background:

  • Childhood chronic diseases are increasing.
  • Cesarean delivery rates have also risen significantly.
  • The relationship between cesarean delivery and idiopathic nephrotic syndrome (INS) relapse is unclear.

Purpose of the Study:

  • To investigate the hypothesis that cesarean section (CS) delivery increases the risk of relapse in children with INS.
  • To analyze the association between birth by CS and the frequency of INS relapses.

Main Methods:

  • A cohort of 56 children diagnosed with INS was studied.
  • Patients were categorized into three groups based on relapse frequency: no relapse (Group A), infrequent relapse (Group B), and frequent relapse (Group C).
  • The proportion of births via CS was compared across these groups.

Main Results:

  • Group C (frequent relapse) had a significantly higher CS rate (37.5%) compared to Group A (0%) and Group B (7.1%).
  • A statistically significant association (P < 0.001) was found between CS delivery and frequent relapses of INS.
  • No children in the no-relapse group were delivered by CS.

Conclusions:

  • Cesarean delivery is associated with an increased risk of relapse in childhood idiopathic nephrotic syndrome.
  • Further research is warranted to understand the underlying mechanisms connecting CS and INS relapse.
  • This finding may inform clinical management and counseling for families affected by INS.

Keywords:
cesarean sectionfrequent relapseidiopathic nephrotic syndromeinfrequent relapse

More Related Videos

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

895
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.4K

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
712
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
263
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
363
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.0K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
359
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
492