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Related Experiment Video

Updated: Feb 19, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
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[Changes of brain function and cognitive function after carotid artery stenting].

Z X Lu1, G Deng, H L Wei

  • 1Southeast University, Nanjing 210009, China.

Zhonghua Yi Xue Za Zhi
|October 31, 2017
PubMed
Summary

Carotid artery stenting (CAS) significantly improved cognitive function in patients with carotid artery stenosis compared to medical treatment. Brain imaging revealed significant changes in brain activity, particularly within the Default Mode Network, suggesting a mechanism for recovery.

Keywords:
AngioplastyCarotid artery stenosisCognitionMagnetic resonance imaging

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Area of Science:

  • Neurology
  • Interventional Radiology
  • Cognitive Neuroscience

Background:

  • Severe internal carotid artery stenosis poses a risk to cognitive function.
  • Carotid artery stenting (CAS) is a treatment option for severe stenosis.
  • The impact of CAS on cognitive and brain function requires further investigation.

Purpose of the Study:

  • To evaluate the effect of CAS on cognitive function using neuropsychological tests.
  • To assess changes in brain function using resting-state functional MRI (fMRI).
  • To compare outcomes between patients undergoing CAS and those receiving medical treatment.

Main Methods:

  • A study involving 33 patients with severe internal carotid artery stenosis.
  • 17 patients received CAS, while 16 served as a control group receiving medical treatment.
  • Neuropsychological tests and fMRI were conducted at baseline and six-month follow-up.

Main Results:

  • The CAS group showed significant improvements in overall cognitive function, including executive function, memory, and attention, compared to the control group.
  • fMRI revealed significant changes in the amplitude of low-frequency fluctuations (ALFF) in various brain regions, including the prefrontal cortex, parietal lobe, and insular cortex.
  • ALFF changes in the insular cortex and motor areas correlated with improvements in specific cognitive tests, such as the Auditory Verbal Learning Test and Frontal Assessment Battery.

Conclusions:

  • CAS leads to significant improvements in cognitive function for patients with carotid artery stenosis compared to medical management.
  • Observed changes in ALFF values in specific brain areas, particularly within the Default Mode Network, indicate potential mechanisms for postoperative neurological recovery.
  • CAS is an effective intervention for enhancing both cognitive and brain function in this patient population.