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Apoptosis during arenavirus infection: mechanisms and evasion strategies
Bjoern Meyer1, Allison Groseth2
1Viral Populations and Pathogenesis Unit, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris cedex 15, France.
Abstract:
In recent years there has been a greatly increased interest in the interactions of arenaviruses with the apoptotic machinery, and particularly the extent to which these interactions may be an important contributor to pathogenesis. Here we summarize the current state of our knowledge on this subject and address the potential for interplay with other immunological mechanisms known to be regulated by these viruses. We also compare and contrast what is known for arenavirus-induced apoptosis with observations from other segmented hemorrhagic fever viruses.
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