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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Related Experiment Video

Updated: Feb 19, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

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Aging as an Epigenetic Phenomenon.

Vasily V Ashapkin1, Lyudmila I Kutueva1, Boris F Vanyushin1

  • 1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.

Current Genomics
|October 31, 2017
PubMed
Summary
This summary is machine-generated.

Epigenetic changes, like DNA methylation, occur during aging and can predict biological age. These age-related epigenetic alterations may be reversible, offering potential for rejuvenation.

Keywords:
AgingDNA methylationEpigenetic ageEpigenetic reprogrammingEpigeneticsHistone modificationmiRNA

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Area of Science:

  • Epigenetics
  • Aging Biology
  • Genomics

Background:

  • Aging involves DNA methylation changes, including hypermethylation of CpG islands and hypomethylation of other genomic regions.
  • Specific CpG sites correlate with age, forming the basis of epigenetic clocks for biological age prediction.
  • Epigenetic regulators like SIRT1 and SIRT6, along with microRNAs (miRNAs), play roles in aging by modulating gene expression and cellular functions.

Purpose of the Study:

  • To explore the role of epigenetic modifications in the aging process.
  • To understand how epigenetic changes contribute to age-related cellular dysfunction and phenotypic variation.
  • To investigate the potential for reversing age-related epigenetic alterations.

Main Methods:

  • Analysis of DNA methylation patterns across the genome during aging.
  • Correlation studies between methylation levels at specific CpG sites and chronological/biological age.
  • Investigation of the function of epigenetic regulators (SIRT1, SIRT6) and miRNAs in aging models.
  • Assessment of transcriptional noise and phenotypic variation in aged cells.

Main Results:

  • Age-related epigenetic drift, including DNA methylation changes, increases transcriptional noise and cellular heterogeneity.
  • Induction of NF-κB pathways and altered miRNA expression are observed in aged tissues, impacting cellular functions.
  • Epigenetic modifications are linked to progressive organ dysfunction in aging mammals.

Conclusions:

  • Epigenetic systems are critical regulators of lifespan across diverse organisms.
  • The epigenome degrades with age due to damage and stress but holds potential for reversal.
  • Age-related epigenetic changes may be partially or fully reversible to a younger state.