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Lysosomal Calcium in Neurodegeneration.

Xinghua Feng1, Junsheng Yang1,2

  • 1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

Messenger (Los Angeles, Calif. : Print)
|October 31, 2017
PubMed
Summary
This summary is machine-generated.

Lysosomes manage cellular recycling and calcium (Ca2+) signaling. Dysregulation of lysosomal Ca2+ contributes to storage diseases and neurodegeneration.

Keywords:
Calcium ChannelsLysosomal Storage DiseasesLysosomesNPCNeurodegenrationRefillingTRPML1

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Area of Science:

  • Cell Biology
  • Neuroscience
  • Biochemistry

Background:

  • Lysosomes are key organelles for macromolecule recycling.
  • Lysosomal dysfunction causes storage diseases and contributes to neurodegeneration.
  • Lysosomes act as intracellular calcium (Ca2+) stores crucial for cellular functions.

Purpose of the Study:

  • To review recent advances in lysosomal calcium regulation.
  • To highlight novel lysosomal calcium channels and refilling mechanisms.
  • To discuss the link between lysosomal calcium defects and neurodegeneration.

Main Methods:

  • Literature review of recent studies on lysosomal calcium.
  • Focus on newly identified lysosomal calcium channels.
  • Analysis of mechanisms for lysosomal calcium store refilling.

Main Results:

  • Recent progress in understanding lysosomal calcium regulation.
  • Identification of new channels involved in lysosomal calcium homeostasis.
  • Elucidation of mechanisms governing lysosomal calcium store refilling.

Conclusions:

  • Lysosomal calcium is vital for cellular processes like signaling and repair.
  • Defects in lysosomal calcium release and storage contribute to lysosomal dysfunction.
  • Impaired lysosomal calcium homeostasis is implicated in neurodegenerative disease pathogenesis.