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Updated: Feb 19, 2026
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Subcellular Imaging of Neuronal Calcium Handling In Vivo
Published on: March 17, 2023
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Lysosomal Calcium in Neurodegeneration
Xinghua Feng1, Junsheng Yang1,2
1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Messenger (Los Angeles, Calif. : Print)
|October 31, 2017
Summary
Lysosomes manage cellular recycling and calcium (Ca2+) signaling. Dysregulation of lysosomal Ca2+ contributes to storage diseases and neurodegeneration.
Area of Science:
- Cell Biology
- Neuroscience
- Biochemistry
Background:
- Lysosomes are key organelles for macromolecule recycling.
- Lysosomal dysfunction causes storage diseases and contributes to neurodegeneration.
- Lysosomes act as intracellular calcium (Ca2+) stores crucial for cellular functions.
Purpose of the Study:
- To review recent advances in lysosomal calcium regulation.
- To highlight novel lysosomal calcium channels and refilling mechanisms.
- To discuss the link between lysosomal calcium defects and neurodegeneration.
Main Methods:
- Literature review of recent studies on lysosomal calcium.
- Focus on newly identified lysosomal calcium channels.
- Analysis of mechanisms for lysosomal calcium store refilling.
Main Results:
- Recent progress in understanding lysosomal calcium regulation.
- Identification of new channels involved in lysosomal calcium homeostasis.
- Elucidation of mechanisms governing lysosomal calcium store refilling.
Conclusions:
- Lysosomal calcium is vital for cellular processes like signaling and repair.
- Defects in lysosomal calcium release and storage contribute to lysosomal dysfunction.
- Impaired lysosomal calcium homeostasis is implicated in neurodegenerative disease pathogenesis.
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