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Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Updated: Feb 19, 2026

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Published on: July 6, 2016

Yeast for virus research.

Richard Yuqi Zhao¹

¹Department of Pathology, Department of Microbiology and Immunology, Institute of Global Health, and Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Microbial Cell (Graz, Austria)

|October 31, 2017

Summary

This summary is machine-generated.

Budding and fission yeasts are valuable models for virus research, offering insights into viral replication and host interactions. Their conserved cellular functions and ease of use make them ideal for studying virus-host dynamics and developing antiviral drugs.

Keywords:

Saccharomyces cerevisiae Schizosaccharomyces pombe cell cycle regulation genome-wide analysis high throughput drug screening programed cell death viral replication virus-host interaction

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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

Area of Science:

Virology
Molecular Biology
Cell Biology

Background:

Budding yeast (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe) are natural hosts for indigenous viruses.
Both yeast species are widely employed to study plant, animal, and human viruses due to conserved cellular functions.
Yeasts offer unique advantages over higher eukaryotes in virus research, including ease of maintenance, rapid growth, and genetic tractability.

Purpose of the Study:

To review the similarities and differences between Saccharomyces cerevisiae and Schizosaccharomyces pombe as model organisms in virology.
To highlight studies on viral activities, including translation, replication, and genome-wide virus-cell interactions within yeast hosts.
To discuss the impact of viral proteins on fundamental cellular processes like cell cycle regulation and programmed cell death.

Main Methods:

Comparative analysis of budding yeast and fission yeast in virus research.
Review of studies investigating viral replication mechanisms in yeast.
Examination of genome-wide analyses of virus-cell interactions in yeast models.

Main Results:

Yeasts support replication of various viruses, including positive-sense RNA and DNA viruses.
Viral activities in yeast provide a platform to study virus-host interactions and their impact on conserved cellular functions.
Viral proteins can modulate essential cellular processes such as cell cycle regulation and programmed cell death in yeast.

Conclusions:

Saccharomyces cerevisiae and Schizosaccharomyces pombe are powerful eukaryotic models for fundamental virology research.
Yeast systems facilitate the study of viral replication, translation, and virus-host interactions.
Yeast-based platforms hold potential for functional analysis of viral genomes and high-throughput screening for antiviral drug discovery.