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Updated: Feb 19, 2026
Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
Published on: December 1, 2015
Mammary and Extramammary Paget's Disease Presented Different Expression Pattern of Steroid Hormone Receptors
Songxia Zhou1, Weixiang Zhong2, Ruiqin Mai3
1Department of Pathology, Shantou University Medical College, Shantou, Guangdong, China.
Background And Objectives:
Paget's disease (PD) is a rare intraepithelial adenocarcinoma, which is composed of mammary (MPD) and extramammary Paget's disease (EMPD). Currently, the published literature contains scant data on expression pattern of steroid hormone receptors in MPD and EMPD.
Methods:
Expression of estrogen receptor (ER) and androgen receptor (AR) was evaluated in 88 MPD and 72 EMPD by using immunohistochemical staining and H-score method.
Results:
Positive expression of AR was significantly higher in EMPD (61.11%, 44/72) than in MPD (32.95%, 29/88) (P < 0.001), while ER expression was positive 19.44% (14/72) in EMPD and only 9.09% (8/88) in MPD (P = 0.059). ER-AR expression pattern was significantly different between MPD (3.41%, 3/88) and EMPD (16.67%, 12/72) (P < 0.001). No difference of AR (P = 0.301) or ER (P = 0.239) expression was identified between invasive (48.57%, 51/105 of AR, and 11.43%, 12/105 of ER) and noninvasive PD. In MPD, no difference of AR expression between MPD alone (7/18, 38.89%) and MPD with underling ductal carcinoma of breast (22/70, 31.43%) was identified (P = 0.548). In EMPD, expression of AR was 63.33% (38/60) in penoscrotal EMPD.
Conclusion:
Our current results indicate that MPD and EMPD presented different expression pattern of AR and ER and would help to further identify the molecular subtype of MPD and EMPD for adjuvant hormonal therapy, especially for patients with penoscrotal EMPD.
Insights
Mammary and extramammary Paget's disease show distinct patterns of estrogen and androgen receptor expression. These findings may guide future adjuvant hormonal therapy decisions, particularly for extramammary Paget's disease.
Area of Science:
- Oncology
- Dermatology
- Endocrinology
Background:
- Paget's disease (PD) encompasses mammary (MPD) and extramammary (EMPD) forms, both rare intraepithelial adenocarcinomas.
- Limited data exists on steroid hormone receptor expression patterns in MPD and EMPD.
Purpose of the Study:
- To investigate and compare the expression patterns of estrogen receptor (ER) and androgen receptor (AR) in MPD and EMPD.
- To identify potential differences that could inform therapeutic strategies.
Main Methods:
- Immunohistochemical staining and H-score method were used to evaluate ER and AR expression.
- The study analyzed 88 cases of MPD and 72 cases of EMPD.
Main Results:
- Androgen receptor (AR) expression was significantly higher in EMPD (61.11%) compared to MPD (32.95%).
- Estrogen receptor (ER) expression was also higher in EMPD (19.44%) versus MPD (9.09%), though the difference was not statistically significant (P=0.059).
- The combined ER-AR expression pattern differed significantly between MPD and EMPD (P < 0.001). No significant differences in AR or ER expression were found between invasive and non-invasive PD.
Conclusions:
- Mammary Paget's disease and extramammary Paget's disease exhibit distinct AR and ER expression profiles.
- These findings aid in molecular subtyping of PD and may guide adjuvant hormonal therapy, especially for penoscrotal EMPD.
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