Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure activity relationships of anxiolytics.

M G Wong1

  • 1Department of Medicinal Chemistry, Victoria College of Pharmacy, Parkville, Australia.

Drug Design and Delivery
|July 1, 1988
PubMed
Summary

Different compounds targeting the benzodiazepine receptor show anxiolytic effects. Researchers studied their shapes and electrical properties to create a model of the drug binding site.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and methods of the REMOVAL-HD study: a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HaemoDialysis patients.

BMC nephrology·2018
Same author

Role of the EGF receptor in PPARγ-mediated sodium and water transport in human proximal tubule cells.

Diabetologia·2013
Same author

Parents of children with cystic fibrosis: how they hope, cope and despair.

Child: care, health and development·2008
Same author

Rational design of alpha-helical antifreeze peptides.

The journal of peptide research : official journal of the American Peptide Society·2002
Same author

Phenylacetate enhances the antiproliferative effect of retinoic acid in follicular thyroid cancer.

Surgery·2001
Same author

Molecular field analysis of clozapine analogs in the development of a pharmacophore model of antipsychotic drug action.

Journal of molecular graphics & modelling·2001

Area of Science:

  • Pharmacology
  • Medicinal Chemistry
  • Molecular Modeling

Background:

  • The benzodiazepine receptor is a target for anxiolytic drugs.
  • Diverse chemical structures can interact with this receptor to produce therapeutic effects.

Purpose of the Study:

  • To understand the structural and electrostatic features of different anxiolytic compounds binding to the benzodiazepine receptor.
  • To develop a predictive model of the benzodiazepine receptor binding site.

Main Methods:

  • Conformational analysis using various techniques.
  • Electrostatic potential mapping.
  • Integration of structural and electrostatic data.

Main Results:

  • Identified distinct conformational preferences among different classes of anxiolytic compounds.
  • Characterized the electrostatic profiles crucial for receptor interaction.
  • Developed a comprehensive model of the benzodiazepine receptor binding site.

Conclusions:

  • Structural and electrostatic properties are key determinants for anxiolytic activity at the benzodiazepine receptor.
  • The developed receptor model can guide the design of new therapeutic agents.
  • Understanding ligand-receptor interactions is crucial for rational drug design.

Related Experiment Videos