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Single-cell Visualization of Chromosome Transcriptional Territories by RNA-paint
Céline Vallot1,2, Claire Rougeulle1,2
1University Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, Paris, France.
Bio-Protocol
|October 31, 2017
Abstract:
We developed a FISH-based method to directly assess chromosome-wide transcriptional activity, thereby enabling the visualization of the actively transcribed fraction of a chromosome at the single-cell level. We applied this method to probe the activity of X-chromosomes and its instability in the context of human embryonic stem cells and cancer cells.
