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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
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Necrotizing soft tissue infections - a multicentre, prospective observational study (INFECT): protocol and

M B Madsen1, S Skrede2,3, T Bruun2

  • 1Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Acta Anaesthesiologica Scandinavica
|October 31, 2017
PubMed
Summary

The INFECT study investigates necrotizing soft tissue infections (NSTIs), analyzing patient data to understand clinical profiles and outcomes. This research aims to improve care for severe NSTI cases.

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Area of Science:

  • Infectious Diseases
  • Clinical Research
  • Epidemiology

Background:

  • Necrotizing soft tissue infections (NSTIs) are severe conditions with high morbidity and mortality.
  • Understanding the pathophysiological mechanisms of NSTIs is crucial for improving patient outcomes.
  • The INFECT project focuses on advancing knowledge in this critical area.

Purpose of the Study:

  • To study the clinical profile of patients diagnosed with NSTIs.
  • To correlate patient characteristics with patient-important outcomes, including mortality and amputation.
  • To identify factors influencing outcomes in NSTI patients.

Main Methods:

  • A multicentre, prospective observational cohort study design.
  • Enrollment of patients with NSTIs across five Scandinavian referral hospitals.
  • Collection of descriptive variables, assessment of affected body parts, skin defect size, and LRINEC scores.

Main Results:

  • The study will provide the largest prospective dataset on NSTI patients to date.
  • Analysis will focus on factors associated with 90-day mortality and amputation.
  • Investigating the impact of acute kidney injury (AKI) and LRINEC scores on mortality.

Conclusions:

  • The INFECT study will yield significant data for clinicians, researchers, and policymakers.
  • Findings will enhance understanding of NSTI patient characteristics and outcomes.
  • This research is expected to inform strategies for managing severe NSTIs.