¹¹ C-PE2I and ¹⁸ F-Dopa PET for assessing progression rate in Parkinson's: A longitudinal study

¹⁸ F-dopa PET measuring aromatic l-amino acid decarboxylase activity is regarded as the gold standard for evaluating dopaminergic function in Parkinson's disease. Radioligands for dopamine transporters are also used in clinical trials and for confirming PD diagnosis. Currently, it is not clear which imaging marker is more reliable for assessing clinical severity and rate of progression. The objective of this study was to directly compare ¹⁸ F-dopa with the highly selective dopamine transporter radioligand ¹¹ C-PE2I for the assessment of motor severity and rate of progression in PD.

Thirty-three mild-moderate PD patients underwent ¹⁸ F-dopa and ¹¹ C-PE2I PET at baseline. Twenty-three were followed up for 18.8 ± 3.4 months.

Standard multiple regression at baseline indicated that ¹¹ C-PE2I BP_ND predicted UPDRS-III and bradykinesia-rigidity scores (P < 0.05), whereas ¹⁸ F-dopa K_i did not make significant unique explanatory contributions. Voxel-wise analysis showed negative correlations between ¹¹ C-PE2I BP_ND and motor severity across the whole striatum bilaterally. ¹⁸ F-Dopa K_i clusters were restricted to the most affected putamen and caudate. Longitudinally, negative correlations were found between striatal Δ¹¹ C-PE2I BP_ND , ΔUPDRS-III, and Δbradykinesia-rigidity, whereas no significant associations were found for Δ¹⁸ F-dopa K_i . One cluster in the most affected putamen was identified in the longitudinal voxel-wise analysis showing a negative relationship between Δ¹¹ C-PE2I BP_ND and Δbradykinesia-rigidity.

Striatal ¹¹ C-PE2I appears to show greater sensitivity for detecting differences in motor severity than ¹⁸ F-dopa. Furthermore, dopamine transporter decline is closely associated with motor progression over time, whereas no such relationship was found with aromatic l-amino acid decarboxylase. ¹¹ C-PE2I may be more effective for evaluating the efficacy of neuroprotective treatments in PD. © 2017 International Parkinson and Movement Disorder Society.