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Cyclin/PCNA is a cell cycle modulated nuclear protein with a role in DNA replication
J E Celis1, P Madsen, H V Nielsen
1Department of Medical Biochemistry, Aarhus University, Denmark.
Abstract:
Cyclin/PCNA (auxiliary protein of DNA polymerase delta) is a proliferation sensitive DNA replication protein whose synthesis is modulated during the cell cycle. All available information suggests that cyclin/PCNA may trigger DNA replication following the formation of pre-replicative complexes at the G1/S transition border.