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A study of intubating conditions: Sevoflurane versus propofol-suxamethonium in children

Morayo M Salawu1, Elizabeth O Ogboli-Nwasor2, Shola S Jamgbadi1

  • 1Department of Anaesthesia and Intensive Care, National Hospital, Abuja, Nigeria.

The Nigerian Postgraduate Medical Journal
|October 31, 2017
PubMed

Insights

Sevoflurane inhalation offers clinically acceptable endotracheal intubation conditions in children, serving as a viable alternative to propofol-suxamethonium. This study recommends sevoflurane for facilitating intubation in pediatric elective procedures.

Area of Science:

  • Anesthesiology
  • Pediatric Surgery

Background:

  • Endotracheal intubation is crucial in pediatric general anesthesia.
  • The choice of induction agents impacts intubation ease and patient outcomes.
  • Comparing sevoflurane and propofol-suxamethonium for pediatric intubation is essential.

Purpose of the Study:

  • To compare the ease of endotracheal intubation using sevoflurane versus propofol-suxamethonium in children.
  • To evaluate intubating conditions and hemodynamic changes during induction.
  • To determine the optimal anesthetic agent for pediatric intubation.

Main Methods:

  • A prospective, randomized, double-blinded comparative study involving 66 children (ages 3-10).
  • Group I: Intravenous propofol and suxamethonium. Group II: Inhalational sevoflurane with nitrous oxide and oxygen.
  • Data analyzed using SPSS, with statistical significance at P < 0.05. Helbo-Hansen score used for intubation ease.

Main Results:

  • Sevoflurane group showed significantly better intubating conditions (P = 0.002) compared to propofol-suxamethonium.
  • Mean time from induction to laryngoscopy was significantly shorter with propofol-suxamethonium (91.27s vs 219.09s; P < 0.0001).
  • Time from laryngoscopy to intubation completion was similar between groups (P = 0.71).

Conclusions:

  • Sevoflurane provides clinically acceptable endotracheal intubating conditions in children.
  • Sevoflurane is a suitable alternative to propofol-suxamethonium for pediatric endotracheal intubation.
  • Recommend sevoflurane for facilitating intubation in elective pediatric procedures.
Abstract

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