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Updated: Feb 19, 2026

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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
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Triblock peptide-oligonucleotide chimeras (POCs): programmable biomolecules for the assembly of morphologically
Andrea D Merg1, Ryan V Thaner, Soumitra Mokashi-Punekar
1Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, USA. nrosi@pitt.edu.
Abstract:
Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are introduced and used to predict and alter POC assembly morphology.

