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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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NM23/NDPK proteins in transcription regulatory functions and chromatin modulation: emerging trends

Shalu Sharma1,2, Antara Sengupta1, Shantanu Chowdhury1,2,3

  • 1Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.

Laboratory Investigation; a Journal of Technical Methods and Pathology
|October 31, 2017
PubMed

Insights

NM23/NDPK proteins, known for suppressing metastasis, also regulate genes and chromatin. This review explores their emerging roles in transcriptional regulation and chromatin modulation for a comprehensive understanding.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • NM23/NDPK proteins are recognized for their role in suppressing tumor metastasis.
  • While nucleotide binding and kinase activities are well-studied, their involvement in metastasis suppression is not fully elucidated.
  • Emerging evidence suggests additional functions beyond enzymatic activities.

Purpose of the Study:

  • To review the emerging roles of NM23/NDPK proteins in gene regulation.
  • To discuss the involvement of NM23/NDPK proteins in chromatin modulation.
  • To provide a comprehensive understanding of the multifaceted functions of NM23/NDPK proteins in cancer.

Main Methods:

  • Literature review of recent studies on NM23/NDPK protein functions.
  • Analysis of emerging reports on transcriptional regulation and chromatin modulation by NM23/NDPK.
  • Synthesis of findings to highlight the diverse roles of NM23/NDPK proteins.

Main Results:

  • NM23/NDPK proteins exhibit functions in transcriptional regulation.
  • These proteins are implicated in modulating chromatin structure.
  • These regulatory roles, alongside enzymatic activities, contribute to metastasis suppression.

Conclusions:

  • NM23/NDPK proteins possess diverse functions including gene and chromatin regulation.
  • Understanding these multifaceted roles is crucial for elucidating metastasis suppression mechanisms.
  • Further research into NM23/NDPK's regulatory functions may reveal novel therapeutic targets.

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