Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune recognition and effector function in subsets of CD4 T cells.

C A Janeway1, J Yagi, J Rojo

  • 1Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510.

Princess Takamatsu Symposia
|January 1, 1988
PubMed
Summary

CD4 T cells are crucial for immune responses. Research shows CD4 acts as a co-receptor with the T cell receptor, and CD4 T cells exist in subsets with distinct functions, requiring specific activation signals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased rupture of cypress pollen type due to atmospheric water in central and southeastern Spain.

The Science of the total environment·2024
Same author

Student-Led Webinar to Support LGBTQ+ Students Applying to Medical School During the COVID-19 Pandemic.

Journal of homosexuality·2023
Same author

Perceptions of change in the environment caused by the COVID-19 pandemic: Implications for environmental policy.

Environmental impact assessment review·2022
Same author

Desert dust intrusions and their incidence on airborne biological content. Review and case study in the Iberian Peninsula.

Environmental pollution (Barking, Essex : 1987)·2022
Same author

Methods for interpolating missing data in aerobiological databases.

Environmental research·2021
Same author

Predicting the Olea pollen concentration with a machine learning algorithm ensemble.

International journal of biometeorology·2020

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD4 T cells are central to adaptive immunity.
  • Understanding their activation and function is key to immune response regulation.

Purpose of the Study:

  • To investigate the role of CD4 in T cell receptor-ligand interactions.
  • To determine if CD4 T cells have distinct functional subsets and their activation requirements.

Main Methods:

  • Studies using cloned T cell lines and normal CD4 T cell populations.
  • Analysis of T cell receptor (TCR) and CD4 molecule interactions with peptide-MHC class II ligands.
  • Investigation of differential activation requirements, including Interleukin-1 (IL-1).

Main Results:

  • CD4 binds to class II MHC molecules, influencing TCR-ligand orientation and antigen recognition.

Related Experiment Videos

  • The V beta chain of the TCR directly recognizes MHC molecules.
  • Two CD4 T cell subsets were identified: one for humoral immunity (requiring IL-1) and one for cell-mediated immunity.
  • Optimal CD4 T cell activation requires peptide-MHC class II recognition and accessory signals.

    • Conclusions:

    • CD4 functions as a co-receptor, enhancing TCR-mediated antigen recognition.
    • CD4 T cells are functionally heterogeneous, with distinct subsets specialized for humoral or cell-mediated immunity.
    • Differential activation signals, like IL-1, dictate the functional outcome of CD4 T cell responses.