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Non-invasive Assessment of Microvascular and Endothelial Function
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Endocan Concentration in Patients With Primary Hypertension
Dominika Musialowska1, Edyta Zbroch1, Ewa Koc-Zorawska1
11 Second Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland.
Angiology
|November 1, 2017
Summary
Patients with primary hypertension have higher endocan levels, potentially indicating endothelial dysfunction. This study compared endocan concentrations in hypertensive patients and healthy individuals, revealing significant differences.
Area of Science:
- Cardiology
- Vascular Biology
- Biochemistry
Background:
- Hypertension pathogenesis involves inflammation and endothelial dysfunction.
- Endocan is implicated in cell adhesion and inflammatory conditions.
Purpose of the Study:
- To compare plasma endocan concentrations between patients with primary hypertension and healthy controls.
- To analyze correlations between endocan, catecholamines, and blood pressure in hypertension.
Main Methods:
- Cross-sectional study comparing 104 hypertensive patients and 21 healthy volunteers.
- Measurement of plasma endocan levels.
- Correlation analysis with catecholamines, body mass index, and leukocyte count.
Main Results:
- Median endocan concentration was significantly higher in hypertensive patients (2.03 ng/mL) versus controls (1.09 ng/mL).
- Positive correlations found between endocan and renalase and norepinephrine.
- Negative correlations observed between endocan and body mass index and leukocyte count.
Conclusions:
- Elevated plasma endocan levels are present in patients with treated, well-controlled primary hypertension.
- Higher endocan concentrations may signify endothelial dysfunction in hypertensive individuals.
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