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Updated: Feb 19, 2026

Author Spotlight: Neutrophil Extracellular Traps Imaging in Human and Mouse Tissues
Published on: August 18, 2023
Neutrophil extracellular traps in patients with pulmonary tuberculosis
Anne Jan van der Meer1, Sacha Zeerleder2,3, Dana C Blok4
1Centre for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105, AZ, Amsterdam, The Netherlands. ajvdrmeer@gmail.com.
Abstract:
Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs release in the circulation during human tuberculosis. For this we measured the plasma concentrations of nucleosomes in conjunction with neutrophil elastase, in 64 patients with active pulmonary tuberculosis and 32 healthy controls. Patients with active tuberculosis had elevated plasma levels of nucleosomes and elastase when compared with local healthy blood donors. Furthermore nucleosome and elastase levels showed a positive correlation. These findings provide the first evidence for the release of NETs in the circulation of patients with active pulmonary tuberculosis.
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