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Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
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Paraganglioma in the bladder: a case report.

Genta Iwamoto1, Takashi Kawahara2, Mikiko Tanabe1

  • 1Division of Diagnostic Pathology, Yokohama City University Medical Center, Yokohama, Japan.

Journal of Medical Case Reports
|November 1, 2017
PubMed
Summary

This case report details a rare bladder paraganglioma diagnosed in an elderly man. The tumor, identified during gastric cancer screening, presented unique diagnostic and management challenges.

Keywords:
Bladder tumorHypertensionParaganglioma

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Area of Science:

  • Urology
  • Oncology
  • Endocrinology

Background:

  • Paraganglioma, a rare tumor arising from extra-adrenal chromaffin cells, can occur in the bladder, representing a very small fraction of bladder neoplasms.
  • This condition is often associated with pheochromocytoma, a related tumor typically found in the adrenal glands.

Observation:

  • A 77-year-old male with gastric cancer was incidentally found to have a bladder tumor.
  • During transurethral resection, a sharp increase in blood pressure was noted, and pathology confirmed paraganglioma.
  • Postoperative imaging and laboratory tests revealed elevated noradrenaline levels and a reduced platelet count.

Findings:

  • The case highlights the diagnostic challenges of bladder paraganglioma, including its association with hypertension during procedures.
  • I-123-metaiodobenzylguanidine scintigraphy confirmed the tumor's nature.
  • Despite diagnosis, treatment was limited due to concurrent advanced gastric cancer.

Implications:

  • This case underscores the importance of considering rare diagnoses like bladder paraganglioma in patients with unexplained symptoms or incidental findings.
  • Early recognition and appropriate diagnostic workup are crucial for managing paraganglioma, even in the presence of other comorbidities.
  • Further research into the management of paraganglioma in the context of other malignancies is warranted.