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Related Experiment Videos

Ontogeny of human suppressor inducer T cell subset.

M Adinolfi1, A Rodin, M Cheetham

  • 1Paediatric Research Unit, United Medical School of Guy's Hospital, London, UK.

Experimental and Clinical Immunogenetics
|January 1, 1987
PubMed
Summary

Newly identified T cell subsets (T4+, 2H4+) induce suppressor cells. These T cells and their molecules are found in blood, not fetal tissues, suggesting late maturation and acquisition in circulation.

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Area of Science:

  • Immunology
  • Cell Biology
  • T cell differentiation

Background:

  • A specific T cell subset, T4+, 2H4+, has been identified as an inducer of T8+ suppressor cells.
  • The 2H4 molecule, characteristic of this subset, has not been found in normal thymuses or immature thymocyte clones.

Purpose of the Study:

  • To investigate the presence and distribution of T4+, 2H4+ and T8+, 2H4+ cells in various human tissues.
  • To determine the stage of T cell maturation associated with the acquisition of 2H4 molecules.

Main Methods:

  • Immunophenotyping of blood, fetal thymus, bone marrow, liver, and spleen samples.
  • Flow cytometry analysis to detect T cell subsets and 2H4 molecule expression.

Main Results:

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  • T4+, 2H4+ and T8+, 2H4+ cells were detected in maternal and newborn blood samples.
  • A low percentage of 2H4+ cells were found in fetal thymus, bone marrow, liver, and spleen.

    • Conclusions:

    • T cells appear to acquire 2H4 molecules in circulation.
    • This acquisition occurs at a late stage of T cell maturation.