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Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
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Exercise improves high fat diet-impaired vascular function.

Jun Fang1, Mei Tang2

  • 1Division of Nephrology, Department of Internal Medicine, Xianning Central Hospital and The First Clinical Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.

Biomedical Reports
|November 1, 2017
PubMed
Summary
This summary is machine-generated.

Swimming exercise combats negative effects of high-fat diets (HFDs). It prevents obesity-related aortic dysfunction by reducing oxidative stress and inflammation, promoting cardiovascular health.

Keywords:
cardiovascular diseaseinflammationobesityoxidative stress

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Area of Science:

  • Cardiovascular Physiology
  • Metabolic Disease Research
  • Exercise Science

Background:

  • Rising rates of metabolic syndrome and cardiovascular disease are linked to high-fat diets (HFDs) and obesity.
  • Aortic function impairment is a concern in HFD-induced obesity.

Purpose of the Study:

  • To investigate if swimming exercise can prevent HFD-induced aortic dysfunction.
  • To determine if exercise reduces oxidative stress and inflammation markers.

Main Methods:

  • Male C57BL/6J mice were fed an HFD (60% lipid) for 16 weeks.
  • One group underwent swimming exercise (90 min/swim, 2 swims/day).
  • Measurements included visceral fat, cholesterol, triglycerides, and aortic function.

Main Results:

  • Exercise training prevented increased visceral fat, cholesterol, and triglycerides.
  • Swimming improved HFD-impaired aortic endothelium-dependent dilation.
  • Exercise reduced oxidative stress, leptin, resistin, MCP-1, IL-6, and IL-8 levels.

Conclusions:

  • Swimming exercise effectively prevents HFD-induced oxidative stress, inflammation, and vascular dysfunction in aortic tissue.
  • Exercise training is a viable strategy to mitigate cardiovascular risks associated with HFDs and obesity.