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Aerosol transmission of Hantaan and related viruses to laboratory rats
E O Nuzum1, C A Rossi, E H Stephenson
1Disease Assessment Division, U.S. Army Medical Research Institute of Infectious Disease, Fort Detrick, Frederick, Maryland 21701-5011.
Abstract:
Hantaan, Seoul, and Puumala viruses were transmitted to 12-16-week-old female Wistar Rattus norvegicus by inhalation. The rodent infectious dose for each virus by intramuscular inoculation and by inhalation was determined, as was the infectious dose for Vero E-6 cells by direct plaque assay.