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Updated: Feb 19, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Novel α-amino acid-derived phase-transfer catalyst application to a highly enantio- and diastereoselective
Yuxin Liu1, Zhonglin Wei, Yu Liu
1Department of Chemistry, Jilin University, Changchun, Jinlin Province, China. linyj@jlu.edu.cn duanhf@jlu.edu.cn.
Abstract:
New quaternary ammonium types of bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors derived from α-amino acids were readily prepared and found to be highly efficient in the asymmetric nitro-Mannich reactions of amidosulfones. Very broad substrate generality was observed, and the products were achieved in high enantio-/diastereoselectivities (90->99.9% ee, 90 : 10 to 92 : 8 dr). Compared with previous reports, the enantioselectivity of aliphatic amidosulfones has been improved to a high level (91-93% ee).
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