Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.4K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.4K
Psychosurgery01:30

Psychosurgery

2.0K
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
2.0K
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

1.9K
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
1.9K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

1.4K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.4K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

1.0K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decoding pre-movement neural activity from thalamic LFPs for adaptive neurostimulation in tremor patients.

Neurocomputing·2026
Same author

Pediatric epilepsy surgery: Global survey of invasive explorations.

Epilepsia·2026
Same author

Seizure and developmental outcomes following epilepsy surgery for children with Sturge-Weber syndrome.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2026
Same author

Sequesterectomy versus standard micro‑/open discectomy for lumbar disc herniation: a systematic review and meta-analysis.

Neurosurgical review·2026
Same author

Routine repeat computed tomography of the head in patients with mild traumatic brain injury: is it really necessary?

Emergency radiology·2026
Same author

Neurophysiologic Biomarkers of Invasive Neuromodulation Therapy for Epilepsy.

Neuromodulation : journal of the International Neuromodulation Society·2026

Related Experiment Video

Updated: Feb 19, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

2.5K

Current Surgical Options for Patients with Epilepsy.

Fahid T Rasul1, Jarnail Bal1, Erlick A Pereira2

  • 1Essex Neurosciences Centre, Barking, Havering and Redbridge University NHS Trust, United Kingdom.

Current Pharmaceutical Design
|November 1, 2017
PubMed
Summary

Epilepsy surgery is a vital treatment for drug-resistant epilepsy, improving seizure control and quality of life. Early referral to specialized centers enhances outcomes for patients undergoing surgical intervention.

Keywords:
Epilepsydeep brain stimulationseizure.surgerytemporal lobevagal nerve stimulation

More Related Videos

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
05:54

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

18.2K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

13.0K

Related Experiment Videos

Last Updated: Feb 19, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

2.5K
Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
05:54

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

18.2K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

13.0K

Area of Science:

  • Neurology
  • Neurosurgery
  • Epileptology

Background:

  • Epilepsy surgery has evolved significantly since 1886.
  • It is a crucial treatment for individuals with pharmacologically resistant epilepsy.
  • Surgical intervention improves seizure control, cognitive function, and overall quality of life.

Purpose of the Study:

  • To review the current landscape of surgical treatments for epilepsy.
  • To discuss presurgical evaluation methods and surgical techniques.
  • To explore future directions in epilepsy surgery.

Main Methods:

  • Review of current literature on epilepsy surgery.
  • Analysis of presurgical evaluation protocols.
  • Examination of various surgical techniques, including resective and neuromodulatory approaches.

Main Results:

  • Epilepsy surgery offers significant benefits for select patients.
  • Mesial temporal lobe sclerosis is the most common epilepsy type treated surgically.
  • Class I evidence supports the efficacy of temporal lobe resection for medium-term seizure control.

Conclusions:

  • Epilepsy surgery is an effective option for drug-resistant epilepsy.
  • Timely referral to experienced epilepsy centers is critical for optimal outcomes.
  • Advancements in technology and research continue to expand surgical possibilities for epilepsy management.