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Published on: August 28, 2018
Preparation of a ferulic acid-phospholipid complex to improve solubility, dissolution, and B16F10 cellular
Li Li1, Yanhong Liu1, Yan Xue1
1Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University, Haidianqufuchenglu 11hao dongqu8haolou 214shi, Beijing, 100048, People's Republic of China.
Background:
We aimed to enhance the solubility, dissolution properties, and skin-whitening ability of ferulic acid (FA) by preparing a ferulic acid-phospholipid complex (FA-PC). The properties and melanogenesis inhibition activities of FA-PC were then elucidated.
Methods:
We characterized the complex via differential scanning calorimetry, Fourier transform infrared spectroscopy, scanning electron microscopy, solubility, and oil-water partition coefficient. A Strat-M® membrane, a synthetic membrane possessing diffusion characteristics that are well-correlated with human skin, was used for the diffusion studies of FA-PC.
Results:
We found that the lipophilicity of FA improved when complexed with phospholipids, allowing FA-PC to release FA in a controlled pattern. In the same time, complexing with phospholipids also obviously enhanced inhibition of B16F10 cellular melanogenesis.
Conclusions:
FA-PC is a promising material for medicinal and cosmetic usages.
