[Myelosupression induced by linezolid: a pediatric case]

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María Del M Ballesteros García1, María E Orós Milián2, Elena Díaz Velázquez2

  • 1Servicio de Pediatría, Hospital Universitario de Fuenlabrada, Madrid, España. mballesterosgarcia@gmail.com.

Archivos Argentinos De Pediatria
|November 1, 2017
PubMed

Insights

Linezolid antibiotic treatment can cause myelosuppression, affecting blood cell production. Monitoring blood counts is crucial during prolonged linezolid therapy to manage potential toxicity.

Area of Science:

  • Pharmacology
  • Hematology
  • Infectious Diseases

Background:

  • Linezolid is a key antibiotic for treating Gram-positive resistant infections.
  • Oxazolidinone class antibiotics inhibit protein synthesis.
  • Common side effects include gastrointestinal issues, neuropathy, and myelosuppression.

Observation:

  • A 12-year-old boy with hip septic osteoarthritis and femoral osteomyelitis received linezolid.
  • The patient experienced digestive intolerance and weight loss.
  • Blood tests revealed severe anemia, leukopenia, and thrombocytopenia, indicating hematopoiesis disorder.

Findings:

  • Hematological abnormalities suggested linezolid-induced drug toxicity.
  • These adverse effects resolved upon discontinuation of linezolid.
  • Myelosuppression is typically associated with linezolid treatment exceeding 28 days.

Implications:

  • This case highlights the potential for reversible myelosuppression with linezolid.
  • Regular blood count monitoring is essential for patients on extended linezolid therapy.
  • Early detection and intervention can mitigate linezolid-related hematological toxicity.
Keywords:
anemialinezolidmyeloid derived suppressorpancytopeniatoxicity

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