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[Pulmonary infection by Arthrographis kalrae in patient with chronic granulomatous disease]

Christian J Campoverde Espinoza1, Carolina M Carballo2, M Nancy Orlando3

  • 1Hospital de Niños Ricardo Gutiérrez, Programa de Infectología Pediátrica, Universidad de Buenos Aires, Facultad de Medicina, Ciudad de Buenos Aires.

Archivos Argentinos De Pediatria
|November 1, 2017
PubMed
Abstract

Insights

Arthrographis kalrae, a rare fungal pathogen, caused severe pneumonia in an immunocompromised child. Treatment with posaconazole led to disease resolution, highlighting a successful therapeutic approach.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pediatric Pulmonology

Background:

  • Arthrographis kalrae is an opportunistic hyaline fungus rarely isolated from human samples.
  • It can cause infections in both immunocompromised and immunocompetent individuals.

Observation:

  • A pediatric case of primary immunodeficiency presented with unilateral pneumonia, progressing to bilateral involvement despite standard treatments.
  • Pulmonary biopsy confirmed Arthrographis kalrae as the causative agent.

Findings:

  • The patient received posaconazole, resulting in complete resolution of the pulmonary infection.
  • This marks the first reported case of Arthrographis kalrae pulmonary infection in a pediatric patient with chronic granulomatous disease in Argentina.

Implications:

  • This case underscores the importance of considering rare fungal pathogens in severe pediatric pneumonia, especially in immunocompromised hosts.
  • Successful treatment with posaconazole provides valuable clinical data for managing similar infections.
  • Highlights the need for increased awareness and diagnostic vigilance for Arthrographis kalrae in clinical settings.
Keywords:
Arthrographis kalraechronic granulomatous diseasepediatrics

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