Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium antagonists--adverse drug interactions.

H Reicher-Reiss1, H N Neufeld, F X Ebner

  • 1Heart Institute, Tel Aviv University, Israel.

Cardiovascular Drugs and Therapy
|December 1, 1987
PubMed
Summary

Calcium channel blockers can interact with other heart medications through pharmacokinetic and pharmacodynamic mechanisms. Understanding these drug interactions is crucial for safe and effective treatment of cardiac patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hospital and 1-year outcome after acute myocardial infarction in patients with diabetes mellitus and hypertension.

Journal of human hypertension·2003
Same author

A prospective study of plasma fibrinogen levels and the risk of stroke among participants in the bezafibrate infarction prevention study.

The American journal of medicine·2001
Same author

Long-term diuretic therapy in patients with coronary disease: increased colon cancer-related mortality over a 5-year follow-up.

Journal of human hypertension·2001
Same author

Prognosis of patients with a recurrent acute myocardial infarction before and in the reperfusion era--a national study.

American heart journal·2001
Same author

Selectively increased risk of cancer in men with coronary heart disease.

The American journal of cardiology·2001
Same author

Is diuretic therapy associated with an increased risk of colon cancer?

The American journal of medicine·2001

Area of Science:

  • Pharmacology
  • Cardiology
  • Clinical Therapeutics

Background:

  • Calcium channel blockers are frequently used with other cardiovascular agents.
  • Drug interactions can occur via pharmacokinetic or pharmacodynamic mechanisms.
  • Adverse interactions can impact patient outcomes in cardiovascular disease management.

Purpose of the Study:

  • To outline potential adverse interactions of major calcium antagonists.
  • To identify interactions with commonly prescribed therapeutic agents.
  • To emphasize the clinical significance of these interactions in cardiac patients.

Main Methods:

  • Review of existing literature on calcium channel blocker interactions.
  • Categorization of interactions based on pharmacokinetic and pharmacodynamic mechanisms.
  • Identification of interacting drug classes including digoxin, beta blockers, antiarrhythmics, anesthetics, antihypertensives, antiasthmatics, antidiabetics, and contrast media.

Main Results:

  • Drug interactions with calcium channel blockers can alter drug absorption, distribution, metabolism, and excretion (pharmacokinetic).
  • Physiologic effects of calcium channel blockers can be antagonized or potentiated by other drugs (pharmacodynamic).
  • Specific interactions with digoxin, beta blockers, and other agents were identified as clinically relevant.

Conclusions:

  • Knowledge of adverse drug interactions involving calcium channel blockers is essential for clinicians.
  • Preventing or managing these interactions improves the safety and efficacy of cardiac patient treatment.
  • This review highlights critical interactions for optimizing therapy in patients with heart disease.

Related Experiment Videos