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Implantable synthetic organoid matrices for intestinal regeneration
Jeffrey W Brown1, Jason C Mills1,2
1Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Nature Cell Biology
|November 1, 2017
Abstract:
Organoids are a powerful tool to study both physiological and disease processes. A completely synthetic matrix assembled from exchangeable modular parts has been developed and not only supports proliferation of human intestinal organoids derived from pluripotent embryonic stem cells, but also augments subsequent ad vivo implantation into injured murine colon.
