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Prognostic Value of Controlled Attenuation Parameter by Transient Elastography.

Ken Liu1,2,3,4, Vincent Wai-Sun Wong1,2,3, Keith Lau1,2,3

  • 1Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong,China.

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Summary
This summary is machine-generated.

Controlled Attenuation Parameter (CAP) measurement does not predict liver-related events, non-hepatocellular carcinoma (HCC) cancers, or cardiovascular events (CVE) in patients with liver disease. This finding indicates hepatic steatosis severity, as measured by CAP, is not a short-term prognostic indicator.

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Area of Science:

  • Hepatology
  • Cardiology
  • Oncology

Background:

  • Liver stiffness measurement (LSM) via transient elastography (TE) predicts patient outcomes.
  • Controlled Attenuation Parameter (CAP) quantifies hepatic steatosis but its prognostic value is unclear.

Purpose of the Study:

  • To assess if CAP predicts liver-related events (LRE), non-hepatocellular carcinoma (HCC) cancers, and cardiovascular events (CVE).

Main Methods:

  • Analysis of consecutive patients with reliable LSM and ≥10 CAP measurements by TE.
  • LRE defined as HCC or hepatic decompensation; CVE defined as acute coronary syndrome, cerebrovascular accident, or coronary intervention.

Main Results:

  • CAP did not predict LRE, non-HCC cancer, or CVE on univariate or multivariate analysis.
  • LSM, male sex, platelet count, serum albumin, and HBV etiology predicted LRE.
  • Age predicted non-HCC cancer; age, fasting blood glucose, total cholesterol, and creatinine predicted CVE.

Conclusions:

  • Hepatic steatosis severity, measured by CAP, does not predict LRE, cancer, or CVE in the short term.