Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

7.1K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.1K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resting-state EEG default mode network connectivity and suicidal ideation in depressive disorders: a retrospective cross-sectional study.

BMC psychiatry·2026
Same author

Reorganization of brain-autonomic integration in alcohol use disorder.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Hot-Melt Pneumatic Extrusion-Based 3D-Printed Bilayer Tablets Enabling Sequential Release of Levocetirizine and Montelukast.

Pharmaceutics·2026
Same author

Neurophysiological indicators of self-efficacy in internet gaming disorder: evidence from late positive potentials.

Frontiers in public health·2026
Same author

Metabolomics analysis of serum biomarkers and metabolic pathways in addictive disorders: Focus on internet gaming disorder and alcohol use disorder.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Association between premenstrual syndrome and postnatal depression in women with recurrent major depressive disorder.

Psychiatry research·2026

Related Experiment Video

Updated: Feb 19, 2026

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
09:01

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

11.6K

Engineered phage nanofibers induce angiogenesis.

So Young Yoo1, Kshitiz Raj Shrestha, Su-Nam Jeong

  • 1BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Republic of Korea. yoosy2@gmail.com yoosy@pusan.ac.kr.

Nanoscale
|November 1, 2017
PubMed
Summary

Engineered M13 bacteriophage nanofibers promote blood vessel growth for soft tissue repair. These phage structures offer a new therapeutic approach for stem cell treatments in ischemic conditions.

More Related Videos

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

9.9K
Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

1.0K

Related Experiment Videos

Last Updated: Feb 19, 2026

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
09:01

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

11.6K
Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

9.9K
Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

1.0K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Soft tissue engineering requires advanced materials to promote vascularization.
  • Angiogenesis, the formation of new blood vessels, is crucial for tissue regeneration.
  • Current therapeutic strategies for ischemic diseases have limitations.

Purpose of the Study:

  • To develop and characterize bioinspired M13 bacteriophage nanofibers as angiogenic agents.
  • To investigate the potential of these nanofibers in soft tissue engineering.
  • To explore their application in stem cell therapies for ischemic diseases.

Main Methods:

  • Biofabrication of M13 bacteriophage into nanofibrous structures.
  • In vitro and in vivo assessment of angiogenic properties.
  • Evaluation of the therapeutic efficacy in stem cell-based models of ischemic disease.

Main Results:

  • Engineered M13 bacteriophage nanofibers successfully induced angiogenesis.
  • The nanofibers provided specific biochemical and topological cues that supported vascularization.
  • Nanofibrous phage structures demonstrated a novel therapeutic platform for stem cell technologies.

Conclusions:

  • M13 bacteriophage can be engineered into effective angiogenic nanofibers for soft tissue applications.
  • These phage-based nanofibers represent a promising biomaterial for regenerative medicine.
  • The study highlights a new therapeutic avenue for treating ischemic diseases using stem cell technology.