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Related Experiment Video

Updated: Feb 19, 2026

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

STCRDab: the structural T-cell receptor database.

Jinwoo Leem¹, Saulo H P de Oliveira¹, Konrad Krawczyk¹

¹Department of Statistics, University of Oxford, 24-29 St Giles, Oxford, OX1 3LB, UK.

Nucleic Acids Research

|November 1, 2017

Summary

This summary is machine-generated.

The Structural T-cell Receptor Database (STCRDab) offers curated T-cell receptor structural data. It aids researchers by providing detailed annotations and enabling comparisons with antibody structures.

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Area of Science:

Immunology
Structural Biology
Bioinformatics

Background:

T-cell receptors (TCRs) are crucial for adaptive immunity.
Understanding TCR structure is vital for immunology and drug development.
A centralized resource for TCR structural data is needed.

Purpose of the Study:

To introduce the Structural T-cell Receptor Database (STCRDab).
To provide a comprehensive, curated online resource for TCR structural information.
To facilitate the study of TCR-ligand interactions and TCR-antibody relationships.

Main Methods:

Automated collection and curation of TCR structural data from the Protein Data Bank.
Annotation of TCR entries with chain pairings (α/β, γ/δ), MHC details, and antigen binding affinities.
Analysis of variable domain orientation and complementarity-determining region (CDR) loop conformations.

Main Results:

STCRDab provides detailed structural annotations for TCRs.
Users can query, view, and download TCR structures based on specific criteria.
The database identifies antibody structures similar to TCRs, aiding comparative studies.

Conclusions:

STCRDab serves as a valuable, accessible resource for TCR structural biology.
The database supports research in adaptive immunity, TCR engineering, and antibody mimicry.
Facilitates exploration of structural similarities between TCRs and antibodies.