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Review: long-acting somatostatin analogues
1City Hospital, Nottingham, UK.
Alimentary Pharmacology & Therapeutics
|June 1, 1987
Summary
This review covers somatostatin and its analogues, focusing on their chemistry and applications. Current uses are limited to carcinoid syndrome, pancreatic tumors, and resistant acromegaly within clinical trials.
Area of Science:
- Pharmacology
- Endocrinology
- Gastroenterology
Background:
- Somatostatin and its analogues are peptide hormones with diverse physiological roles.
- Their therapeutic potential is explored for various endocrine and gastrointestinal conditions.
Purpose of the Study:
- To review the chemistry, actions, and chemical applications of somatostatin and its analogues.
- To outline current and potential clinical uses in gastroenterology and endocrinology.
Main Methods:
- Literature review of somatostatin and analogue research.
- Analysis of clinical applications and trial data.
Main Results:
- Somatostatin analogues show promise in managing carcinoid syndrome and functioning pancreatic endocrine tumors.
- Their use in resistant acromegaly is under investigation.
- Broader application is currently restricted to clinical trials.
Conclusions:
- Somatostatin analogues have specific, established roles in managing certain gastrointestinal and endocrine disorders.
- Further research and clinical trials are necessary to define their full therapeutic potential and expand their application.