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SODD promotes glucose uptake of colorectal cancer cells via AKT pathway

Rui Zhang1, Jibin Li1, Xiaofei Yan1

  • 1Department of Colorectal Surgery.

Cell Biology International
|November 1, 2017
PubMed

Insights

Silencer of death domains (SODD) promotes colorectal cancer growth by increasing glucose uptake. Inhibiting SODD may offer a new therapeutic strategy for colorectal cancer.

Area of Science:

  • Oncology
  • Cancer Metabolism
  • Molecular Biology

Background:

  • Altered glucose metabolism is a hallmark of cancer, but its underlying mechanisms remain unclear.
  • Understanding cancer-specific metabolic regulation is crucial for developing effective therapies.

Purpose of the Study:

  • To investigate the role of silencer of death domains (SODD) in regulating glucose metabolism in colorectal cancer.
  • To explore SODD as a potential therapeutic target for colorectal cancer.

Main Methods:

  • Clonogenic assays were performed on colorectal cancer cell lines (RKO and SW1417) with varying SODD expression levels under low glucose conditions.
  • Cell viability, glucose transporter 1 (GLUT1) expression, glucose uptake, and AKT phosphorylation were assessed.
  • The effects of GLUT1 and AKT inhibition on SODD-induced glucose uptake were evaluated.

Main Results:

  • SODD overexpression enhanced colorectal cancer cell viability and colony formation, particularly under low glucose conditions.
  • SODD upregulation led to increased GLUT1 expression and elevated glucose uptake.
  • AKT phosphorylation was upregulated in SODD-overexpressing cells, and inhibiting GLUT1 or AKT reversed the enhanced glucose uptake.

Conclusions:

  • SODD positively regulates glucose uptake in colorectal cancer cells.
  • SODD plays a significant role in promoting colorectal cancer cell growth and survival.
  • SODD represents a potential therapeutic target for colorectal cancer treatment.
Keywords:
AKTGLUT1SODDcolorectal cancerglucose metabolism

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