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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Feb 19, 2026

Experimental Metastasis Assay

Experimental Metastasis Assay

Published on: August 24, 2010

HCMDB: the human cancer metastasis database.

Guantao Zheng^1,2, Yijie Ma¹, Yang Zou¹

¹Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China.

Nucleic Acids Research

|November 1, 2017

Summary

This summary is machine-generated.

Cancer metastasis leads to patient death. This study integrates transcriptomic data into the Human Cancer Metastasis Database (HCMDB) for better understanding of cancer spread.

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Last Updated: Feb 19, 2026

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Area of Science:

Oncology
Bioinformatics
Genomics

Background:

Metastasis is a primary cause of cancer-related mortality.
High-throughput technologies have generated extensive transcriptomic data on cancer metastasis.
Existing data are fragmented across repositories, hindering comprehensive analysis.

Purpose of the Study:

To create an integrated platform for analyzing metastasis-related transcriptome data.
To facilitate systems-biology research into the mechanisms of cancer metastasis.
To provide a freely accessible resource for the research community.

Main Methods:

Development of the Human Cancer Metastasis Database (HCMDB).
Integration of diverse microarray and RNA sequencing datasets.
Creation of a queryable, cross-platform data mining platform.

Main Results:

HCMDB provides a centralized repository for metastasis-related gene expression data.
Enables efficient analysis of transcriptomic changes associated with cancer spread.
Facilitates identification of genes involved in the metastatic phenotype.

Conclusions:

HCMDB serves as a valuable resource for cancer metastasis research.
Integrated data analysis promotes a systems-biology approach to understanding metastasis.
The database supports in-depth investigation of metastasis-related transcriptome data.