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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
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Predictive Value of Underweight Status for Patients With Peripheral Artery Disease With Claudication

Keisuke Senda1, Takashi Miura1, Masatoshi Minamisawa1

  • 11 Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Angiology
|November 2, 2017
PubMed

Insights

Underweight status in peripheral artery disease (PAD) patients with claudication is linked to worse outcomes. This study found underweight PAD patients had higher mortality rates, emphasizing the need for weight management.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Nutritional Science

Background:

  • Peripheral artery disease (PAD) affects lower limb circulation.
  • Claudication is a common symptom of PAD, excluding critical limb ischemia.
  • The prognostic impact of underweight status in PAD patients with claudication requires further investigation.

Purpose of the Study:

  • To evaluate the association between underweight status and prognosis in patients with PAD presenting with claudication.
  • To determine if body mass index (BMI) influences mortality and cardiovascular outcomes in this patient group.

Main Methods:

  • Retrospective analysis of 441 claudicant patients hospitalized for cardiovascular disease (2005-2012).
  • Patients categorized into four BMI groups: underweight (<18.5 kg/m²), normal (18.5-25.0 kg/m²), overweight (25.0-30.0 kg/m²), and obese (≥30.0 kg/m²).
  • Outcomes assessed included all-cause and cardiovascular death over a mean follow-up of 3.5 years, using multivariate Cox analysis.

Main Results:

  • Underweight patients (n=48) exhibited significantly poorer clinical markers, including lower hemoglobin, albumin, eGFR, triglycerides, and HbA1c, alongside higher CRP and BNP.
  • The underweight group showed a higher prevalence of hemodialysis.
  • Incidence of all-cause death (77.1% vs 33.0%) and cardiovascular death (43.3% vs 14.4%) was significantly higher in underweight patients compared to normal BMI patients.
  • Underweight status independently predicted all-cause mortality (HR, 2.53; 95% CI, 1.58-4.18).

Conclusions:

  • Underweight status is a significant independent predictor of poor prognosis and increased mortality in patients with PAD and claudication.
  • Clinical management strategies for PAD patients should consider nutritional status and promote weight gain.
  • Addressing underweight status may be crucial for improving outcomes in PAD patients.

Keywords:
body mass indexintermittent claudicationmortalityperipheral artery diseaseunderweight

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