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Effects of indomethacin on bone ingrowth
J C Keller1, T M Trancik, F A Young
1Department of Materials Science, Medical University of South Carolina, Charleston.
Summary
Indomethacin, a nonsteroidal anti-inflammatory drug, halts bone ingrowth over time in rabbits. Bone ingrowth was unaffected by implant pore size in this study.
Area of Science:
- Orthopedic research
- Pharmacology
- Biomaterials science
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used.
- The impact of NSAIDs on bone healing requires further investigation.
- Porous implants are utilized to promote bone regeneration.
Purpose of the Study:
- To investigate the effect of indomethacin on bone ingrowth.
- To determine the influence of implant pore size on bone ingrowth.
- To assess the temporal changes in bone ingrowth with and without indomethacin treatment.
Main Methods:
- A rabbit animal model was employed.
- Porous cylindrical implants with varying pore sizes (0.6-1.0 mm) were used.
- Indomethacin or placebo was administered, and bone ingrowth was measured at 2 and 8 weeks.
Main Results:
- Bone ingrowth was independent of pore size within the tested range.
- Control animals showed significant bone ingrowth between 2 and 8 weeks.
- Indomethacin-treated animals exhibited no increase in bone ingrowth over time.
Conclusions:
- Indomethacin significantly inhibits bone ingrowth progression.
- Implant pore size did not influence bone ingrowth in this model.
- Further research is needed to understand NSAID effects on bone healing.