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Updated: Feb 19, 2026

A Nanobar-Supported Lipid Bilayer System for the Study of Membrane Curvature Sensing Proteins in vitro
Published on: November 30, 2022
The Unsolved Problem of How Cells Sense Micron-Scale Curvature
Kevin S Cannon1, Benjamin L Woods1, Amy S Gladfelter1
1Department of Biology, University of North Carolina at Chapel Hill, NC, USA.
Abstract:
Membrane curvature is a fundamental feature of cells and their organelles. Much of what we know about how cells sense curved surfaces comes from studies examining nanometer-sized molecules on nanometer-scale curvatures. We are only just beginning to understand how cells recognize curved topologies at the micron scale. In this review, we provide the reader with an overview of our current understanding of how cells sense and respond to micron-scale membrane curvature.
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