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Updated: Feb 19, 2026
11:12
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
23.2K
[Deep brain stimulation in parkinsonian patients with dopa intolerance]
Pedro J García-Ruiz1, Cici Feliz-Feliz1, Joaquín Ayerbe Gracia2
1Servicio de Neurología, Fundación Jiménez Díaz, Madrid, España.
Neurocirugia (English Edition)
|November 2, 2017
Summary
Deep brain stimulation (DBS) offers an alternative for Parkinson's patients intolerant to levodopa. Careful patient selection is key, but DBS can be effective even with severe levodopa intolerance if an acute response is observed.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Deep brain stimulation (DBS) is an established treatment for advanced Parkinson's disease (PD) with motor complications.
- Optimal outcomes with DBS depend heavily on precise patient selection criteria, including a documented positive response to levodopa.
Observation:
- This report details two cases of early-onset Parkinson's disease.
- Both patients exhibited severe intolerance to levodopa but demonstrated a significant and lasting response to DBS.
Findings:
- Deep brain stimulation can be a viable therapeutic option for Parkinson's patients experiencing severe levodopa intolerance.
- The success of DBS in these cases was contingent upon achieving an acute positive response to either levodopa or apomorphine.
Implications:
- These findings suggest that DBS may be considered for a broader range of Parkinson's patients, including those with medication intolerance.
- Careful patient selection, focusing on acute medication response, remains paramount for successful DBS implementation in challenging cases.
Keywords:
Deep brain stimulatEnfermedad de ParkinsonEstimulación cerebral profundaIntolerancia a levodopaLevodopa intoleranceParkinson's diseaseMore Related Videos
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