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Prevention of cancer at the urothelial enteric anastomotic site
C Shands1, W S McDougal, E P Wright
1Department of Urology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
The Journal of Urology
|January 1, 1989
Abstract:
An animal model of ureterosigmoidostomy was employed to elucidate the etiology of urinary intestinal anastomotic cancer. One hundred ninety-four rats were divided into five groups: vesicosigmoidostomy rats fed water without drug (controls); those fed ammonium chloride, or sodium bicarbonate, or ascorbic acid; and, finally, vesicosigmoid interposition rats. A significantly decreased incidence of cancer was evident only in the bowel interposition group (p less than 0.001). Ascorbic acid and altered urinary pH were not prophylactic. Possible mechanisms are discussed.