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Protective effect of HTK solution on postoperative pulmonary function in infants with CHD and PAH

Jindong Li1, Yanhong Wu1, Xudong Tian1

  • 1Department of Cardiac Surgery, Liao Cheng People's Hospital, Liaocheng 252000, Shandong, China.

Bioscience Reports
|November 2, 2017
PubMed

Insights

Pulmonary arterial perfusion with Histidine-tryptophan-ketoglutarate (HTK) effectively protected infant lungs after heart surgery. This method reduced lung injury and improved respiratory function in infants with congenital heart disease and pulmonary arterial hypertension.

Area of Science:

  • Cardiology
  • Pediatric Surgery
  • Pulmonary Medicine

Background:

  • Congenital heart disease (CHD) and pulmonary arterial hypertension (PAH) pose significant risks in infants undergoing cardiopulmonary bypass (CPB).
  • Lung injury is a common complication following CPB in this vulnerable population.

Purpose of the Study:

  • To evaluate the efficacy of pulmonary arterial perfusion (PAP) using Histidine-tryptophan-ketoglutarate (HTK) solution for lung protection in infants with CHD and PAH post-CPB.
  • To assess the impact of HTK on inflammatory markers and respiratory function.

Main Methods:

  • A randomized study of 50 infants with CHD and PAH undergoing CPB.
  • Serum levels of IL-6, MDA, and ET-1 were measured using ELISA.
  • Oxygen index (OI) and respiratory index (RI) were calculated; mechanical ventilation, ICU, and hospital stays were recorded.

Main Results:

  • HTK group showed significantly lower levels of IL-6, MDA, and ET-1 post-CPB compared to the control group.
  • The control group experienced a marked decrease in OI and increase in RI post-CPB.
  • HTK administration resulted in shorter mechanical ventilation, ICU, and hospital stays, with reduced lung inflammation and edema.

Conclusions:

  • Pulmonary arterial perfusion with HTK solution is effective in mitigating CPB-induced lung injury in infants with CHD and PAH.
  • HTK improves lung function and reduces postoperative complications, offering a protective strategy.
Abstract

Keywords:
Congenital heart diseaseHTKLung functionPulmonary arterial hypertensionPulmonary arterial perfusion

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